This correlation may be useful for anticipating the need for repeat plasmapheresis. Apart from that, there are various applications where you will need to use the viscosity tester. Serum viscosity and electrophoresis are recommended before and after plasmapheresis in order to correlate viscosity and M-spike with patient symptoms. It is the reason why it is important to test the viscosity of a particular product before packing it. Hyperviscosity syndrome can also occur in multiple myeloma patients.īecause the ability of a monoclonal protein to cause hyperviscosity is affected by its concentration, molecular weight, and aggregation, sera with concentrations of monoclonal IgM greater than 4 g/dL, IgA greater than 5 g/dL, or IgG greater than 6 g/dL should be tested for hyperviscosity. Using a viscometer, such as a Brookfield Viscometer, for measuring the viscosity of semi-solids like creams, gels and pastes, can be tricky.
The most common cause of serum hyperviscosity is the presence of large concentrations of IgM monoclonal proteins, and Waldenstrom macroglobulinemia accounts for 80% to 90% of hyperviscosity cases. Funduscopic examination reveals dilation of retinal veins and flame shaped retinal hemorrhages.
Note 1: If the liquid is non-Newtonian, that is shear-thinning or thixotropic, Test Methods D2196 should be used. Hyperviscosity may be manifested by nasal bleeding, blurred vision, headaches, dizziness, nystagmus, deafness, diplopia, ataxia, paresthesias, or congestive heart failure. 1.1 This test method covers the determination of the flow time (viscosity) of Newtonian and near-Newtonian paints, and related coatings and products using ISO capillary flow cups. Viscosity is the property of fluids to resist flow.
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